Axioms: The body produces around 20mg cortisone daily. More than 20mg hydrocortisone causes adrenal suppression. The synthetic ones produce less suppression. Above the physiologic level (bolded above), side effects rise dramatically.
Signs: In all patients consider that signs of infection may be suppressed. Cushingoid appearance: moon face, hirsutism, buffalo hump, flushing, increased bruising, striae, acne.
Why Corticosteroids Are Bad For You:
- Osteoporosis
- Muscle wasting
- Skin thinning
- Hyperglycaemia
- Adrenal atrophy - via negative feedback on the hypothalamic-pituitary-adrenal axis.
- Masked infections - anti-inflammatory, analgesic and antipyretic
- Menstrual irregularities
- Hypercoaguability - embolism
FAQ:
Prednisolone is not Prednisone. The latter requires hepatic metabolism to be converted into its active form.
Above the physiologic dose, many patients report feeling sick and unwell.Updated 15/4/12
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